The Site of Bone Marrow Acquisition Affects the Myeloid to Erythroid Ratio in Apparently Healthy Dogs.
Identifieur interne : 000783 ( Main/Exploration ); précédent : 000782; suivant : 000784The Site of Bone Marrow Acquisition Affects the Myeloid to Erythroid Ratio in Apparently Healthy Dogs.
Auteurs : Arnon Gal [Nouvelle-Zélande] ; Richard K. Burchell [Nouvelle-Zélande] ; Andrew J. Worth [Nouvelle-Zélande] ; Nicolas Lopez-Villallobos [Nouvelle-Zélande] ; Jonathan C. Marshall [Nouvelle-Zélande] ; Amy L. Macneill [États-Unis]Source :
- Veterinary pathology [ 1544-2217 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Cellules de la moelle osseuse (cytologie), Cellules myéloïdes (cytologie), Cellules érythroïdes (cytologie), Chiens (anatomie et histologie), Cytoponction (), Cytoponction (médecine vétérinaire), Femelle, Humérus (cytologie), Ilium (cytologie), Maladies des chiens (anatomopathologie), Moelle osseuse (anatomie et histologie), Mâle, Prélèvement biologique (), Prélèvement biologique (médecine vétérinaire).
- MESH :
- anatomie et histologie : Chiens, Moelle osseuse.
- anatomopathologie : Maladies des chiens.
- cytologie : Cellules de la moelle osseuse, Cellules myéloïdes, Cellules érythroïdes, Humérus, Ilium.
- médecine vétérinaire : Cytoponction, Prélèvement biologique.
- Animaux, Cytoponction, Femelle, Mâle, Prélèvement biologique.
English descriptors
- KwdEn :
- Animals, Biopsy, Fine-Needle (methods), Biopsy, Fine-Needle (veterinary), Bone Marrow (anatomy & histology), Bone Marrow Cells (cytology), Dog Diseases (pathology), Dogs (anatomy & histology), Erythroid Cells (cytology), Female, Humerus (cytology), Ilium (cytology), Male, Myeloid Cells (cytology), Specimen Handling (methods), Specimen Handling (veterinary).
- MESH :
- anatomy & histology : Bone Marrow, Dogs.
- cytology : Bone Marrow Cells, Erythroid Cells, Humerus, Ilium, Myeloid Cells.
- methods : Biopsy, Fine-Needle, Specimen Handling.
- pathology : Dog Diseases.
- veterinary : Biopsy, Fine-Needle, Specimen Handling.
- Animals, Female, Male.
Abstract
Bone marrow (BM) cytology and histopathology are complementary tools used to investigate hematological diseases. The purpose of this study was to determine if there are site-dependent differences in the diagnostic quality, myeloid to erythroid ratio (MER), and discordant findings in samples from different sites in the same dog. Eighteen apparently healthy dogs were used in the study. The sequence of sample acquisition was randomized according to a Latin square, and samples for BM cytology and histology were collected from both humeri and both ilial crests immediately after death. Board-certified clinical and anatomical pathologists read the cytology and histology, respectively. The data were analyzed using a mixed-effect model. The site of BM acquisition did not affect BM sample quality. The rate of discordant clinical findings between sites was 0.05 (95% confidence interval, 0.01-0.13). In general, by cytology, the MERs were slightly but significantly greater in samples from the ilial crests than from the humeri ( P = .01). The measured MER for histology was nearly twice that for cytology for all sites ( P < .001). In conclusion, there was a low-rate, site-dependent discordance in diagnostic findings in BM samples and differences in MER between the ilial crest and the humerus. A similar study is justified in sick dogs with hematological disease to determine the effect of sampling site on discordant findings between sites.
DOI: 10.1177/0300985818780469
PubMed: 29940832
Affiliations:
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Burchell</name><affiliation wicri:level="1"><nlm:affiliation>1 School of Veterinary Science, Massey University, Palmerston North, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>1 School of Veterinary Science, Massey University, Palmerston North</wicri:regionArea><wicri:noRegion>Palmerston North</wicri:noRegion></affiliation></author><author><name sortKey="Worth, Andrew J" sort="Worth, Andrew J" uniqKey="Worth A" first="Andrew J" last="Worth">Andrew J. 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Macneill</name><affiliation wicri:level="2"><nlm:affiliation>3 Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author></analytic><series><title level="j">Veterinary pathology</title><idno type="eISSN">1544-2217</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biopsy, Fine-Needle (methods)</term><term>Biopsy, Fine-Needle (veterinary)</term><term>Bone Marrow (anatomy & histology)</term><term>Bone Marrow Cells (cytology)</term><term>Dog Diseases (pathology)</term><term>Dogs (anatomy & histology)</term><term>Erythroid Cells (cytology)</term><term>Female</term><term>Humerus (cytology)</term><term>Ilium (cytology)</term><term>Male</term><term>Myeloid Cells (cytology)</term><term>Specimen Handling (methods)</term><term>Specimen Handling (veterinary)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules de la moelle osseuse (cytologie)</term><term>Cellules myéloïdes (cytologie)</term><term>Cellules érythroïdes (cytologie)</term><term>Chiens (anatomie et histologie)</term><term>Cytoponction ()</term><term>Cytoponction (médecine vétérinaire)</term><term>Femelle</term><term>Humérus (cytologie)</term><term>Ilium (cytologie)</term><term>Maladies des chiens (anatomopathologie)</term><term>Moelle osseuse (anatomie et histologie)</term><term>Mâle</term><term>Prélèvement biologique ()</term><term>Prélèvement biologique (médecine vétérinaire)</term></keywords><keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Chiens</term><term>Moelle osseuse</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies des chiens</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Bone Marrow</term><term>Dogs</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules de la moelle osseuse</term><term>Cellules myéloïdes</term><term>Cellules érythroïdes</term><term>Humérus</term><term>Ilium</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bone Marrow Cells</term><term>Erythroid Cells</term><term>Humerus</term><term>Ilium</term><term>Myeloid Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy, Fine-Needle</term><term>Specimen Handling</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Cytoponction</term><term>Prélèvement biologique</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dog Diseases</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Biopsy, Fine-Needle</term><term>Specimen Handling</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cytoponction</term><term>Femelle</term><term>Mâle</term><term>Prélèvement biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bone marrow (BM) cytology and histopathology are complementary tools used to investigate hematological diseases. The purpose of this study was to determine if there are site-dependent differences in the diagnostic quality, myeloid to erythroid ratio (MER), and discordant findings in samples from different sites in the same dog. Eighteen apparently healthy dogs were used in the study. The sequence of sample acquisition was randomized according to a Latin square, and samples for BM cytology and histology were collected from both humeri and both ilial crests immediately after death. Board-certified clinical and anatomical pathologists read the cytology and histology, respectively. The data were analyzed using a mixed-effect model. The site of BM acquisition did not affect BM sample quality. The rate of discordant clinical findings between sites was 0.05 (95% confidence interval, 0.01-0.13). In general, by cytology, the MERs were slightly but significantly greater in samples from the ilial crests than from the humeri ( P = .01). The measured MER for histology was nearly twice that for cytology for all sites ( P < .001). In conclusion, there was a low-rate, site-dependent discordance in diagnostic findings in BM samples and differences in MER between the ilial crest and the humerus. A similar study is justified in sick dogs with hematological disease to determine the effect of sampling site on discordant findings between sites.</div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li><li>États-Unis</li></country><region><li>Colorado</li></region></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Gal, Arnon" sort="Gal, Arnon" uniqKey="Gal A" first="Arnon" last="Gal">Arnon Gal</name></noRegion><name sortKey="Burchell, Richard K" sort="Burchell, Richard K" uniqKey="Burchell R" first="Richard K" last="Burchell">Richard K. Burchell</name><name sortKey="Lopez Villallobos, Nicolas" sort="Lopez Villallobos, Nicolas" uniqKey="Lopez Villallobos N" first="Nicolas" last="Lopez-Villallobos">Nicolas Lopez-Villallobos</name><name sortKey="Marshall, Jonathan C" sort="Marshall, Jonathan C" uniqKey="Marshall J" first="Jonathan C" last="Marshall">Jonathan C. Marshall</name><name sortKey="Worth, Andrew J" sort="Worth, Andrew J" uniqKey="Worth A" first="Andrew J" last="Worth">Andrew J. Worth</name></country><country name="États-Unis"><region name="Colorado"><name sortKey="Macneill, Amy L" sort="Macneill, Amy L" uniqKey="Macneill A" first="Amy L" last="Macneill">Amy L. Macneill</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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